ketoconazole is an imidazole fungicidal agent with a very broad spectrum of activity against many fungal species that is used for treatment of superficial and systemic fungal infections. This compound is approved by FDA for the treatment of CKD especially its inhibit CYP24A1.

Liarozole lack specificity since they suppress steroidogenesis by interfering with a wide range of cytochrome P450 enzyme systems, even though this property might be advantageous in the therapy of prostate cancer and CKD

Clinical Trial-PhaseIII.