Dr. M. Karthikeyan

Research Supervisor , Department of Bioinformatics

Research Guidance

Area of Research

  • Human Molecular Genetics
  • Pharmacogenomics & Computer Aided Drug discovery
  • Cancer Biology
  • Database Creation and Development
  • Plant Based Medicine for Diabetes and Snake bites

Doctor of Philosophy (Bioinformatics): (Completed: 05 ||Thesis Submitted: 02 ||On Going: 01)

  1. Pharmacogenomics and computer assisted designing of antihypertension lead molecules (March 2014). Kh. Dhanachandra Singh Alagappa University, Karaikudi- 630 004. (Awarded)
  2. Computational identification and in vitro validation of novel lead molecules against TOPK and tankyrase proteins (May 2014). P. Kirubakaran. Alagappa University, Karaikudi- 630 004. (Awarded)
  3. A study on potential antidiabetic properties of Syzygium densiflorum fruits by in vitro, in vivo and in silico approaches. (July 2016). Gopinath. K. Alagappa University, Karaikudi- 630 004. (Awarded)
  4. The Genetic and Molecular Mechanism of Vitamin D Receptor (VDR) in Chronic Kidney Disease (CKD) Pathogenesis. S. Nagamani . Alagappa University, Karaikudi- 630 004. (Awarded)
  5. Screening, Isolation and Identification of Potent Anti-Snake venome Molecules from Clematis Gouriana Roxb. Ex Dc. C. SathishKumar . Alagappa University, Karaikudi- 630 004. (Awarded)
  6. Role of RAS and CYP gene polymorphisms in Anti hypertensive treatment: a Pharmacogenomics and Computational study.
    L. Lakshmanan (Thesis Submitted)

  7. Pharmacogenomics and Computational Studies of VDR, CYP24A1 and Klotho genes among Chronic Kidney Disease Patients in Indian Population. J. John Marshal (Thesis Submitted).

  8. Molecular Inhibition Of SH3BP2 and KIT Crosstalk Signalling Mechanism Downregulates Colorectal Cancer Pathogenesis: A Computational And Experimental Analysis. J. Muralidharan (On-going).

Master of Philosophy (Bioinformatics): (Completed: 08)

  • Atom-based Beta-1 adrenoreceptor antagonists QSAR study: on insight into the structural basis of anti hypertensive activity (April 2011) Pugalenthi .S, Alagappa University, Karaikudi- 630 004.
  • Identification and theoretical evaluation of Novel MurF inhibition in antibacterial therapy (November 2012) Ilakkiya P, Department of Bioinformatics, Bharathidasan University, Tiruchirappalli-24 (External Guide : Theoretical Studies)
  • Structure based 3D-QSAR studies of Jak2 inhibitors and extensive pharmacophore based virtual screening to identify potent Jak2 inhibitors (June 2013) E. Queen Naveena, Alagappa University, Karaikudi- 630 004.
  • Role of hydrophobic patch in LRP6: A molecular dynamics study (June 2014),  Swaraj Prasad, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Computational studies on Tankyrase-Axin complex: Identification of  potential inhibitors for colon cancer (June 2017), R. Sheela Rani, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Computational studies on RNF146-AXIN complex: Identification of potential inhibitors for colon cancer (July 2018), N. Keerthana, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Role of SH3BP2 Protein in Cancer Pathogensis: A Computational Cross Section of the SH3BP2 Cell Signaling Mechanism. L. Aruna.(2019). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.

  • In Silico Insights On The Identification Of Potential Sfrp1 Protein: A Potential Target For Colorectal Cancer. P.Komatha Malarvizhi (2020). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.

Master of Science (Bioinformatics): (Completed: 34 || On Going: -)

  • Structure-Based Drug Design of EphrinhA2 Receptor Antagonist from Marine Compounds (April 2010) Nagamani. S, Dr G R Damodran College of Science, Coimbatore- 641014
  • Docking of Adenosine Analogue to Inhibit Elavivirus RNA dependant RNA polymerase (RdRp) (April 2010) Manikandaprabhu. S, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Ligand Based Lead Discovery of Parb-1 Inhibitors (May 2010) Mohamed Rabeek. N, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Structure Based virtual Screening to identify the potential beta 2 Adrenoceptor Antagonist (May 2010) Muthulaksmi. S, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Molecular Docking Study on Anticancer activity of Bitter Melon Derived Natural compounds (May 2010) Sindhu. S, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Structure-Based Lead Discovery of ApoE4 Antagonist from Plant Compound (April 2010) Sathya A V, Dr G R Damodran College of Science, Coimbatore- 641014
  • High throughput screening and simulation studies on homology modeled T-Lymphokine Activated Killer Cell Originated Protein Kinase from Homo sapiens (April 2011) Archana .V.P, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Prediction of alpha-2A adrenergic receptor agonism and antagonism by combined ligand and structure based screening (April 2011) Joseph Arul Rayan. A, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Discovery of potent and selective inhibitors of Human Aldosterone Synthase (CYP11B2) by combined Pharmacophore and structure based screening (April 2011) Prabhu. D, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Understanding the evolutionary pattern of HA gene of H1N1 (2009) Influenza virus: a sequence and structure based approach (2012) S. Bhuvaneshwari, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • The agonist and antagonist mechanism of (23S)-25-Dehydro-1α-Hydroxy Vitamin D3-26,23-Lactone in Vitamin D Receptor (VDR) (2012) G. Mahendra Krishna, Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Computational identification of Immunodominant Antigenic region and Envelope protein inhibitors against Dengue virus (2013) D. Nandhini, Department of Bioinformatics, Alagappa University, Karaikudi- 04.
  • Computational Validation of Rupestonic acid derivatives as H1N1, H3N2 and Influenza B virus inhibitors by pharmacophore modeling, atom based 3D-QSAR, CoMFA⁄CoMSIA and docking studies (2013) T. Raja Rajeshwari, Department of Bioinformatics, Alagappa University, Karaikudi- 04.
  • Computational studies on Influenza A virus (H1N1) Neuraminidase Mutants (2014) J. Alosius, Alagappa University, Karaikudi- 04.
  • Computational identification of potent lead molecules for Chronic Kidney Disease  (2014) J. John Marshal, Department of Bioinformatics, Alagappa University, Karaikudi- 04.
  • Molecular Docking and Molecular Dynamics Studies on Ellagic acid Derivatives Against Snake Venom Phospholipase A2 (PLA2) (2015) V. Jagasirpian, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • A Quantum Mechanics/Molecular Mechanics study of the protein-ligand interactions for VDR agonists (2015) S. Saravanakumar, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • A Quantum Mechanic/Molecular Mechanic study of the wild-type and mutant VDR complexed with calcitriol (2016) R. Sheela Rani, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Molecular Docking and Molecular Dynamics Studies on Bioactive Compounds from Clematis gouriana Roxb. ex DC. against Snake Venom Metalloproteinase (SVMP) (2016) P. Pappathi, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Identification of potent active compounds against SUB3 protein of Dermatophyted: An in silico study (2016) R. Kanimozhi , Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Identification of potent inhibitor for TNKS 2: a computational study (2017). B. Josephine Julia, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Combined Structure and Pharmacophore Based Screening Approach for the Identification of Potent Tankyrase 1 Inhibitors (2017). Afrinrilwana K. , Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Computational insights of Klotho protein agonist molecules (2018). K. Anushuya, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Combined structure and ligand based pharmacophore modeling and molecular dynamic simulation studies against VDR agonist. Everlene Reteti, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Revealing potent inhibitors against intracellular domain of Renin Receptor for the treatment of Hypertension. S.R.Logeshwaran (2019). Department of Biotechnology and Bioinformatics, Bishop Henber College, Tiruchirapalli-620017.
  • Computational screening of missense mutation and identification of potent inhibitor against CYP2D6 and CYP3A4 genes.
    S. Karthikeyan     (2019). Department of Biotechnology and Bioinformatics, Bishop Henber College, Tiruchirapalli-620017.
  • Investigation of non-covalent interactions and binding mode of the identified lead compounds targeting GSAP for the treatment of Alzheimer’s Disease. P. Elavazhagan (2019). Department of Biotechnology and Bioinformatics, Bishop Henber College, Tiruchirapalli-620017.
  • Role of CYP24A1 Gene Mutation A326G in Chronic Kidney Disease: A computational study. S. Soundarya (2019). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • A computational study on GPR56 agonist: structure and pharmacophore based screening and MD stimulation. S. Muthuselvi (2019). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • In silico insights on the identification of potential SFRP1 protein: A potential target for ovarian cancer. G.Logeshwari (2021). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • In silico analysis of potential compounds targeted towards klotho protein for chronic kidney disease. M. Anitha (2021). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.
  • Identification of Potential Agonist of Drug Target (BDNF) Involved in the Pathogenesis of Migraine and Anxiety: An In silico Approach. S.Sakthi Sasikala (2022). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.

  • Mechanical Insight On Vitamin D Role And Screening Of Potential Lead Molecule Against Parkinson’s Disease: A Computational Approaches. S.Thanga Nivetha (2022). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.

  • Structure And Ligand Based Drug Design Approach For The Theoretical Investigation Of PDGFRα Inhibition. N. Vijay (2022). Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, India.

PG. Diploma in Structural Pharmacogenomics : (Completed: 05 || On Going: -)

  • Molecular Dynamics and Molecular Docking studies on Phospholipase A2 (PLA2) (2014) C. SathishKumar , Department of Bioinformatics, Alagappa University, Karaikudi- 630 004.
  • Identification of potent inhibitors against NS3 helicase protein of Zika virus: Combined Molecular docking and Dynamics study (2016). L. Lakshmanan, Department of Bioinformatics, Alagappa University, Karaikudi – 630 004.
  • Insilico investigation of the binding mechanism of wild and Mutant type CYP2D6 complexed with tamoxifen (2016). J. John Marshal, Department of Bioinformatics, Alagappa University, Karaikudi – 630 004.
  • Anaerobic process for Bioplastic (PHB) production using dairy industrial waster water (2017). G.H. Dinesh, Department of Microbiology, Alagappa University, Karaikudi – 630 004.
  • Computational insights on RNF146-TNKS protein complex: Identification of potential inhibitors for colon cancer (2018). N. Keerthana, Department of Bioinformatics, Alagappa University, Karaikudi – 630 004

Short-term Training :(Completed: 01)

  • Basic Molecular Biology techniques and Bioinformatics tools (December 2012)  R. Y. Ramanathan (II year B.Tech Student) Dept. of Genetic Engineering, SRM university, SRM Nagar, Kattankulathur – 603 203

Master of Technology (Bioinformatics): (Completed: 01)

  • Molecular modeling study on a chemically diverse series of Angiotensin Type 1 receptor antagonists: Homology modeling, 3D-QSAR and MM/GBSA free energy calculation (2012) Ranjani. M,  Bharathidasan University, Tiruchirappalli-24